The wing sustained an injury to his right ankle in Sarries' loss to Wasps earlier this month and had surgery this week. He is expected to be out of action for 12 weeks.
Maitland has scored eight tries during his first season with the club after his move from London Irish and will be unavailable for the Premiership semi-final at Exeter Chiefs this Saturday.
The 28-year-old will also miss the decider on May 27, should the holders, who have retained their European Champions Cup crown, reach the domestic showpiece at Twickenham.
Scotland coach Gregor Townsend has called up wing Rory Hughes and full-back Greig Tonks to replace Maitland for the matches against Italy in Singapore, Australia in Sydney and Fiji in Suva next month.
BREAKING | Head Coach Gregor Townsend adds Rory Hughes & Greig Tonks to Scotland summer tour squad after Maitland ruled out through injury. pic.twitter.com/caWZSIGNxj
— Scottish Rugby (@Scotlandteam) May 18, 2017