Around 61 million prescriptions were made in 2015, more than double the 30 million written in 2005, according to the University College London study.
The average patient now takes medication for six months, compared to just under four months in 1995.
But the number of people diagnosed with depression is almost unchanged.
Your experiences on anti-depressants
Lauren Harris, 23 - 'It's an easy solution for the NHS'
"I've been on various anti-depressants for the last five years, since I turned 18," Lauren tells Newsbeat.